Nogo‐B limits intima‐media thickening during mouse vein graft adaptation
نویسندگان
چکیده
منابع مشابه
A novel vein graft model: adaptation to differential flow environments.
Accelerated intimal hyperplasia in response to altered flow environment is critical to the process of vein bypass graft failure. Lack of a reproducible animal model for dissecting the mechanisms of vein graft (VG) remodeling has limited progress toward solving this clinically significant problem. Combining a cuffed anastomotic technique with other surgical manipulations, we developed a well-def...
متن کاملVenous identity is lost but arterial identity is not gained during vein graft adaptation.
OBJECTIVES Ephrin ligands and Eph receptors are signaling molecules that are differentially expressed on arteries and veins during development. We examined whether Eph-B4, a venous marker, and Ephrin-B2, an arterial marker, are regulated during vein graft adaptation in humans and aged rats. METHODS AND RESULTS Eph-B4 transcripts and immunodetectable protein are downregulated in endothelial an...
متن کاملLocally applied cilostazol suppresses neointimal hyperplasia and medial thickening in a vein graft model.
BACKGROUND Pathological changes in vein grafts begin immediately after arterial circulation is applied to the grafts. Chemical mediator stimulation and mechanical strain induce neointimal hyperplasia and medial thickening of the vein grafts, resulting in their failure. We investigated the inhibitory effect of locally applied cilostazol, an inhibitor of cyclic adenosine monophosphate phosphodies...
متن کاملInhibition of vein graft intimal and medial thickening by periadventitial application of a sulfated carbohydrate polymer.
PURPOSE The purpose of this study was to determine whether the wall thickening observed in vein grafts after they were placed into the arterial circulation could be inhibited by periadventitial delivery of an insoluble sulfated polymer of beta-cyclodextrin (P-CDS) capable of tightly binding heparin binding growth factors. METHODS Thirty-four New Zealand white rabbits underwent implantation of...
متن کاملTheoretical approach on vein graft survival: simulation on vein graft
Artery reconstruction in upper extremities is rare performed compared to artery reconstruction in lower extremities. Primary vascular repair was performed in many cases. An interposition vein graft or venous bypass grafting were applied in order to alleviate thrombus in blood vessel. However, one or more of the applied vein graft are blocked or severely narrowed due to the mismatched internal d...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2008
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.22.1_supplement.174.4